Roybal, K.T., Williams, J.Z., Morsut, L., Rupp, L.J., Kolinko, I., Choe, J.H., Walker, W.J., McNally, K.A., Lim, W.A. (2016) Engineering T Cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors. Cell. 167, 419-432 See article
Summary: SynNotch T cells drive customized therapeutic responses for cancer and other diseases. SynNotch T cells can be engineered to sense tumor antigens and locally deliver biologics such as antibodies, and can thus be used as a smart platform for local delivery of diverse therapeutic payloads capable of remodeling microenvironments.
Researchers including faculty member Brian Shoichet develop safer opioid painkiller from scratch:
An international team of researchers — led by scientists at UC San Francisco, Stanford University, the University of North Carolina, and the Friedrich-Alexander University Erlangen-Nürnberg in Germany — has developed a new opioid drug candidate that blocks pain without triggering the dangerous side effects of current prescription painkillers. Read more:http://www.universityofcalifornia.edu/news/researchers-develop-safer-opi...
PSPG faculty member Dr. Les Benet presented the 2016 commencement address and was also the recipient of the 2016 Outstanding Mentor Award conferred by the Associated Students of the Graduate Division Alumni Association: http://graduate.ucsf.edu/commencement-celebration-2016
Congratulations PSPG Alumni Max Seibold! The NJH Office of Academic Affairs and the Center for Genes, Environment and Health has announce the creation of a Program in Regenerative Medicine and Genome Editing (REGEN) to be directed by Max A. Seibold, Ph.D. The overall mission of the program will be to advance regenerative medicine approaches for understanding the etiology of, and advance potential therapies for, lung and immunological diseases. Initially, the REGEN program will focus on the establishment of stem cell techniques, including induced pluripotent stem cell (iPSC) derivation and experimentation at National Jewish Health. A main emphasis of the program will also be on the modification of disease genes and genetic variants in iPSCs for disease modeling and therapy. Dr. Seibold will name Assistant Directors for the program and engage the broader NJH community in seminars regarding the program this fall.
Congratulations to PSPG Student Rosa Chan who has received one of five 2016 American Association of Pharmaceutical Scientists (AAPS) Graduate Student Fellowships! Election to Fellow status is based on the individual's documented sustained level of superior and distinguished professional achievement and contributions to the field. Rosa's work focuses on understanding the association of drug hypersensitivity reactions of HLA-B families and their interactions with small molecules.